1.Talent researchers
1.1. Dr. Trần Mạnh Hùng
MH Tran obtain BS degree majoring in Biotechnology and Pharmacy in 2002. After that, Dr. Tran moved to Korea and gained master and PhD in Pharmecautical sciences at College of Pharmacy, Chungnam National University, Korea. Dr Tran's main research area is to search for active ingredients from natural medicinal plants with biological activities against cancer, diabetes, Alzheimer's disease and inflammatory. Dr. Tran had over 15 years of experience in research and development of natural products. Dr. Tran have been worked in many positions in Japan, Korea and the US. He had 1 patent registered in Korea and 03 useful solutions that are waiting to be approved in Vietnam this year. Dr. Tran currently is a member of the Scientific Council of Nafosted in the field of biomedicine and pharmacology. Dr. Tran has published many domestic and international scientific articles in the field of natural medicines. Tran is now working at Dong A University, Danang city, Vietnam as a Dean of Scientific Management Department.
1.2. Dr. Pham Tran Vinh Phu
Pham Tran Vinh Phu graduated BSc in 2007 on Biotechnology Engineering from Danang University of Technology-Vietnam and PhD in Biomedical Sciences in 2018 at University of Tsukuba, Japan with Molecular Virology group. Then, I worked as a scientist researcher at the same place until 2019. During 5 years in Japan, I was mainly focusing on mechanism of human adaptation of avian influenza viruses. I started working as a teaching assistance in the Department of Biotechnology, Faculty of Chemical Engineering, Danang University of Technology. Until 2019, I moved to Department of Biomedical Sciences, VN-UK Institute for Research and Executive Education (VNUK), the University of Danang. In here, I was working as a lecturer and a scientist researcher during one year. At the present, I am the Vice Dean of Faculty of Medicine, Dong A University, Vietnam. My research interests are the biotechnological applications, infectious diseases, and human health as well as environmental aspects.
1.3. Dr. Le Ngoc Quang
Quang Ngoc Le has a BA in Vietnamese Studies (Culture and Tourism) and MEd in Leadership and Management from Quang Nam University, Vietnam and National Chung Cheng University, Taiwan R.O.C respectively. He served the Danish Refugee Council/Danish Demining Group in Vietnam with the roles being Information Management as well as Training Facilitator. Since 2017, he has been working in roles of advisor and knowledge officer in both Vietnam and Thailand. He is now working as Deputy Director of Scientific Management Department, Dong A University, Vietnam. He was awared Ph.D in Information Studies at Khon Kaen University, Thailand in 2021. His research interests are knowledge sharing, knowledge needs, and knowledge management in the non-profit sector.
2. Research projects
2.1. Building a short supply chain model for agricultural products in Dak Lak province, Vietnam
Professor Hoa Huu Lan of Dong A University's Department of Scientific Management is leading the project. The goal of this research project is to develop a short supply chain application framework for providing the products and to evaluate the production and distribution of three current key products. Then, in Dak Lak province, put your theories into reality by developing and evaluating three distinctive short supply chain models for agricultural products. Furthermore, the project offers solutions and recommendations for achieving good implementation results in Dak Lak province
2.2. Development of a Capillary Electrophoretic Method for the Determination of Huperzine A Concentration in Vietnamese Huperzia serrata
Huperzine A, isolated from Huperzia serrata, is a potent, specific, and reversible inhibitor of acetylcholinesterase with high efficiency and low toxicity. To evaluate the presence of huperzine A in Vietnamese H serrata, a reliable capillary zone electrophoresis method was developed. The analytical conditions were established using 80 mM ammonium acetate buffer, pH 6.0, hydrodynamic injection at 50 mbar for 5 s, applied voltage of 20 kV, temperature at 25 °C, uncoated fused-silica capillary, 56 cm (50 cm effective length) × 70 µm inner diameter, and ultraviolet detection at 310 nm. The recovery rates ranged from 98.05% to 100.64%, with a relative standard deviation <2%. Good linear regression was observed in the concentration range of 1 to 500 µg/mL, with a correlation coefficient of 0.9994. The limit of detection and limit of quantification were 0.33 and 1.0 µg/mL, respectively. These results demonstrate that this method is simple, selective, and suitable for performing quality control for huperzine A derived from Vietnamese H serrata.
2.3. On the Inhibitability of Natural Products Isolated from Tetradium ruticarpum towards Tyrosine Phosphatase 1B and α-Glucosidase
Mr. Tran Manh Hung, the head of the scientific management department, led the study effort, which aimed to discover natural compounds that may be used to cure diabetes. The initiative is praised for its relevance and urgency in today's society. The results showed that two natural compounds derived from the plant Tetradium ruticarpum have strong inhibitory ability on tyrosine phosphatase 1B (PTP1B) and α-glucosidase enzymes - two enzymes that play an important role in the treatment of diseases. type 2 diabetes.
3. Patents
3.1. Dr. Tran Manh Hung - Dong A University published a book chapter on "Study on the effects of traditional Chinese medicine CTH in the treatment of cirrhosis, experimented on Wistar rats"
On March 3, 2021, Dr. Tran Manh Hung, Head of the Department of Scientific Management, Dong A University, and domestic authors published “Study on the effects of traditional Chinese medicine CTH in the treatment of cirrhosis” (“Effects of cthepab, a Traditional Vietnamese Medicinal Formulation, on the Treatment of Cirrhosis in Wistar rats”).
Cirrhosis is a type of liver disease that causes long-term, widespread damage. Cirrhosis is characterized by inflammatory forms, such as necrosis of liver parenchyma cells; fibrous proliferation of connective tissue causes fibrosis scarring and the formation of granules regenerated from intact hepatocytes, upsetting the normal structure and causing lumps in the liver parenchyma, as well as loss of liver function.
Cirrhosis has been on the rise in recent years, according to projections, as a result of hepatitis B and C virus infection and rising alcohol consumption in many parts of the continent. Cirrhosis of the liver kills an estimated 800,000 individuals per year around the world. Dr. Hung's research team has been consistently investigating and approaching technical breakthroughs to find a strategy that is helpful in the treatment of cirrhosis of the liver, realizing the need for researching and producing treatments to prevent and limit cirrhosis.
The research team discovered that the traditional medicine CTH had an effective effect on the treatment of cirrhosis in the Wistar mouse model of cirrhosis during the Wistar rat investigation. To aid in physical fitness, CTH is made from a cure containing herbal elements such as prickly pear, small leaf milkweed, Chi Tu, Rhubarb, Dinh Lang, Cordyceps, Lingzhi, Ha thu o... AST, ALT, hydroxyproline concentration in the liver, plasma albumin, and prothrobin activity in the blood
The research team's success has opened the way for the development of CHT capsules for the treatment of cirrhosis in patients, confirming the Vietnamese research team's reputation in the pharmaceutical area. Dr. Hung's research team is working hard to create and perform further research so that CTH products can reach cirrhosis sufferers as soon as possible.
4. News from researchers/projects
4.1. Study on extracting and isolating curcumin, oil from residues of turmeric starch production from some yellow turmeric varieties in Quang Nam province
Ms. Nguyen Thi Anh Dao, Rector of Dong A University, is in charge of the project. Scientifically, research is valued and used in the production of local products. According to the findings, yellow turmeric cultivars with high amounts of Curcuminoids in Quang Nam province are ideal as raw materials for the manufacturing of turmeric starch, Curcumin, and turmeric oil. Then, from residues of turmeric starch manufacturing from Yellow Turmeric in Quang Nam province, extracting and isolating Curcumin with a 95% content and turmeric oil were conducted.
Source: nguyenlieuyduoc.com.vn
The project will be completed and tested on fruit in 2022, according to the plan. This is a project that has the potential to bring new healthy products to market as well as open up new economic opportunities.
4.2. Analyses and evaluation the antibacterial activity of extracts from leaves of Ampelopsis cantoniensis and Cleistocalyx operculatus with adjuvant applications in the treatment of patients with skin infections.
Dr. Pham Tran Vinh Phu, Associate Professor of Medicine at Dong A University, conducted the research with the goal of analyzing and evaluating the antibacterial activity of extracts from Ampelopsis cantoniensis and Cleistocalyx operculatus leaves as adjuvants in the treatment of patients with skin infections.
The study below is being carried out in collaboration with the Danang Department of Science and Technology and will be finished in 2022.